Invitrogen

CD68 Polyclonal Antibody

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CD68 Antibody in Immunocytochemistry (ICC/IF)

CD68 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD68 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-89134

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

免疫组化 (IHC)

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 22-319 of human CD68 (NP_0012422)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.57 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2805377

产品详细信息

Positive Samples: Mouse fat, Mouse skin, Rat skin; Cellular Location: Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein, Single-pass type I membrane protein

Immunogen sequence: NDCPHKKSAT LLPSFTVTPT VTESTGTTSH RTTKSHKTTT HRTTTTGTTS HGPTTATHNP TTTSHGNVTV HPTSNSTATS QGPSTATHSP ATTSHGNATV HPTSNSTATS PGFTSSAHPE PPPPSPSPSP TSKETIGDYT WTNGSQPCVH LQAQIQIRVM YTTQGGGEAW GISVLNPNKT KVQGSCEGAH PHLLLSFPYG HLSFGFMQDL QQKVVYLSYM AVEYNVSFPH AAQWTFSAQN ASLRDLQAPL GQSFSCSNSS IILSPAVHLD LLSLRLQAAQ LPHTGVFGQS FSCPSDRS

靶标信息

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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PA5-89134 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that the systematic intervention targeting different pathophysiological links of AGA by the combination of organic drug and bioactive metal ions is an effective treatment strategy for hair loss, which provides a theoretical basis for development of biomaterial based anti-hair loss therapy.

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Mellouk A,Hutteau-Hamel T,Legrand J,Safya H,Benbijja M,Mercier-Nomé F,Benihoud K,Kanellopoulos JM,Bobé P

Published figure using CD68 polyclonal antibody (Product # PA5-89134) in Immunohistochemistry

Tue Oct 18 00:00:00 EDT 2022

Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Lee MH,Sanders L,Kumar R,Hernandez-Saavedra D,Yun X,Ford JA,Perez MJ,Mickael C,Gandjeva A,Koyanagi DE,Harral JW,Irwin DC,Kassa B,Eckel RH,Shimoda LA,Graham BB,Tuder RM

PA5-89134 was used in Immunohistochemistry to find upregulated pulmonary arterial transcription of 26 and 13 FAO genes in idiopathic and systemic sclerosis-associated PAH, respectively.