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CD8 Antibody (C11205) in Flow
Samples were acquired and analyzed using 405 nm excitation and 522/31 nm band pass emission filters on an Attune® Acoustic Focusing Cytometer (Life Technologies, Carlsbad, CA). The histogram shows cells stained with CD8 Mouse Anti-Human Pacific Green™ Conjugate (black line), and unstained cells (gray line).
产品信息
C11205
产品规格
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
3B5
抗原
Recognizes the CD8 antigen
偶联物
激发/发射光谱
415/502 nm
查看光谱
形式
Liquid
保存条件
4° C
靶标信息
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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