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CD80 Antibody (BS-2211R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat brain tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-CD80 Polyclonal Antibody, Unconjugated (bs-2211R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB ... View More
产品信息
BS-2211R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from rat CD80.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activation B7-1 antigen; B-lymphocyte activation antigen B7; B7; B7 protein; BB1; CD80; Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1); CD80 antigen; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; sCD 80; sCD80; soluble CD 80; soluble CD80; T-lymphocyte activation antigen CD80; TS/A-1
基因别名: B7; B7-1; B7.1; B71; BB1; Cd28l; CD28LG; CD28LG1; CD80; LAB7; Ly-53; Ly53; MIC17; TSA1
UniProt ID: (Human) P33681, (Mouse) Q00609
Entrez Gene ID: (Human) 941, (Mouse) 12519, (Rat) 25408
cell-cell signaling
positive regulation of signal transduction
regulation of phosphatidylinositol 3-kinase signaling
T cell costimulation
intracellular signal transduction
T cell activation
positive regulation of interleukin-2 biosynthetic process
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of alpha-beta T cell proliferation
viral entry into host cell
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to lipopolysaccharide
positive regulation of T cell proliferation
