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CD9 Antibody (PA5-95868) in IHC (P)
Immunohistochemistry analysis of CD9 in paraffin-embedded human smooth muscle. Samples were incubated with CD9 Polyclonal antibody (Product # PA5-95868) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-95868
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 112-195 of human CD9 (NP_0017601)
偶联物
形式
Liquid
浓度
1.42 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807670
产品详细信息
Immunogen sequence: SHKDEVIKEV QEFYKDTYNK LKTKDEPQRE TLKAIHYALN CCGLAGGVEQ FISDICPKKD VLETFTVKSC PDAIKEVFDN KFHI; Positive Samples: Mouse kidney; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein
靶标信息
CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5H9; 5H9 antigen; antigen CD9; BA-2/p24 antigen; BA2; CD9; CD9 antigen; CD9 antigen (p24); Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; motility related protein-1; Motility-related protein; MRP-1; p24; sCD 9; sCD9; soluble CD 9; soluble CD9; Tetraspanin-29; Tetraspanin29; Tspan-29
基因别名: BTCC-1; CD9; DRAP-27; GIG2; MIC3; MRP-1; TSPAN-29; TSPAN29
UniProt ID: (Human) P21926, (Mouse) P40240, (Rat) P40241
Entrez Gene ID: (Human) 928, (Mouse) 12527, (Rat) 24936
movement of cell or subcellular component
cell adhesion
single fertilization
fusion of sperm to egg plasma membrane
negative regulation of cell proliferation
paranodal junction assembly
platelet degranulation
cell surface receptor signaling pathway
brain development
response to water deprivation
oligodendrocyte development
platelet activation
receptor internalization
cellular response to low-density lipoprotein particle stimulus
