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CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BR-cadherin; Brain cadherin; brain-cadherin; Cadherin; cadherin 12, type 2 (N-cadherin 2); cadherin, neural type, 2; Cadherin-12; N-cadherin 2; Neural type cadherin 2; neuronal cadherin 2
基因别名: CDH12; CDHB
UniProt ID: (Human) P55289
Entrez Gene ID: (Human) 1010