Proteintech

CDK6 Polyclonal Antibody, CoraLite® Plus 647

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抗体检测数据 (1)

CDK6 Antibody in Flow Cytometry (Flow)

CDK6 Antibody in Flow Cytometry (Flow)

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CDK6 Antibody (CL647-19117) in Flow

1X10^6 HeLa cells were intracellularly stained with 0.2 µg CoraLite® Plus 647 Anti-Human CDK6 (CL647-19117) (red), or 0.2 µg isotype control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).

CDK6 Antibody in Flow Cytometry (Flow)

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CDK6 Antibody in Flow Cytometry (Flow) — 1X10^6 HeLa cells were intracellularly stained with 0.2 µg CoraLite® Plus 647 Anti-Human CDK6 (CL647-19117) (red), or 0.2 µg isotype control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).

产品信息

CL647-19117

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cell suspension

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产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Fusion Protein

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偶联物

CoraLite® Plus 647 CoraLite® Plus 647 CoraLite® Plus 647

激发/发射光谱

654/674 nm

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

PBS with 0.5% BSA, 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, store in dark

运输条件

Wet ice

产品详细信息

Immunogen sequence: MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF QDLERCKENL DSHLPPSQNT SELNTA

靶标信息

CDK6 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene results in microcephaly 12, primary, autosomal recessive (MCPH12).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cell division protein kinase 6; CR2 protein kinase; CRK2; Cyclin-dependent kinase 6; MGC59692; Serine/threonine-protein kinase PLSTIRE

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基因别名: 5830411I20; AI504062; CDK6; CDKN6; Crk2; MCPH12; PLSTIRE

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UniProt ID: (Human) Q00534, (Mouse) Q64261

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Entrez Gene ID: (Human) 1021, (Rat) 114483, (Mouse) 12571

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cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding cyclin binding kinase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

参与通路

G1/S transition of mitotic cell cycle positive regulation of cell-matrix adhesion type B pancreatic cell development protein phosphorylation cell cycle arrest Notch signaling pathway negative regulation of cell proliferation response to virus regulation of gene expression positive regulation of gene expression astrocyte development dentate gyrus development lateral ventricle development T cell differentiation in thymus gliogenesis cell dedifferentiation negative regulation of cell differentiation negative regulation of myeloid cell differentiation regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of osteoblast differentiation negative regulation of cell cycle positive regulation of fibroblast proliferation generation of neurons negative regulation of epithelial cell proliferation cell division hematopoietic stem cell differentiation cellular response to phorbol 13-acetate 12-myristate regulation of cell motility negative regulation of cellular senescence hematopoietic progenitor cell differentiation phosphorylation hemopoiesis cell cycle cell differentiation regulation of cell proliferation