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产品信息
P14ARF-101AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
N-epitope synthetic peptide corresponding to unique amino acid sequence on p14ARF protein
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
靶标信息
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein, ARF (p14ARF in human and P19ARF in mouse). These two proteins interact with the upstream proteins: retinoblastoma protein and p53 tumor suppressors, respectively. Each of these proteins has a role in the senescence of primary cells, activates pathways for cell cycle control and tumor suppression. The p14ARF (or P19ARF in mouse) proteins can induce both G1 and G2 phase arrest in a manner that depends on functional p53. The mouse and human ARF proteins have different functions in tumor suppression; this distinction may contribute to the different levels of tumor proneness of these species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alternative reading frame; ARF; CDK4 inhibitor p16-INK4; CDK4I; cdkn2a; cdkn2a {ECO:0000312|EMBL:AAL76336.1, ECO:0000312|RGD:2323}; cdkn2a {ECO:0000312|EMBL:AAL76338.1, ECO:0000312|RGD:2323}; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; inhibits CDK4; mitochondrial smARF; MTS-1; Multiple tumor suppressor 1; p14 p16; p14ARF; p16; p16-INK4; p16-INK4a; P19 TP16; p19ARF; Tumor suppressor ARF
基因别名:
ARF; ARF-INK4a; CDK4I; CDKN2; CDKN2A; CMM2; INK4; INK4A; INK4a-ARF; Ink4a/Arf; MLM; MTS-1; MTS1; P14; P14ARF; P16; p16(INK4a); P16-INK4A; p16Cdkn2a; P16INK4; P16INK4A; P19; p19
UniProt ID: (Human) Q8N726, (Mouse) Q64364, (Rat) Q9R0Z3
Entrez Gene ID: (Human) 1029, (Mouse) 12578, (Rat) 25163
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
protein kinase binding
poly(A) RNA binding
NF-kappaB binding
p53 binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein N-terminus binding
ubiquitin-protein transferase inhibitor activity
MDM2/MDM4 family protein binding
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
protein polyubiquitination
mitophagy
negative regulation of cell-matrix adhesion
transcription, DNA-templated
regulation of transcription, DNA-templated
rRNA processing
negative regulation of protein kinase activity
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle
cell cycle arrest
aging
cell aging
negative regulation of cell proliferation
epidermis development
apoptotic mitochondrial changes
rRNA transcription
response to organonitrogen compound
regulation of G2/M transition of mitotic cell cycle
regulation of gene expression
response to organic cyclic compound
negative regulation of cell growth
negative regulation of B cell proliferation
regulation of protein stability
protein destabilization
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein binding
negative regulation of immature T cell proliferation in thymus
positive regulation of protein sumoylation
negative regulation of mammary gland epithelial cell proliferation
positive regulation of smooth muscle cell apoptotic process
somatic stem cell population maintenance
senescence-associated heterochromatin focus assembly
negative regulation of phosphorylation
response to drug
glucose homeostasis
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleocytoplasmic transport
regulation of protein export from nucleus
somatic stem cell division
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of ubiquitin-protein transferase activity
mitochondrial depolarization
positive regulation of apoptotic process involved in mammary gland involution
cellular response to hydrogen peroxide
protein K63-linked ubiquitination
positive regulation of cell cycle arrest
cellular senescence
replicative senescence
positive regulation of protein localization to nucleus
positive regulation of signal transduction by p53 class mediator
regulation of apoptotic DNA fragmentation
negative regulation of proteolysis involved in cellular protein catabolic process
regulation of protein targeting to mitochondrion
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of macrophage apoptotic process
positive regulation of cellular senescence
Ras protein signal transduction
response to organic substance
cerebellum development
