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Bethyl Laboratories
CEACAM8/CD66b Recombinant Rabbit Monoclonal Antibody (BLR111H)
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CEACAM8/CD66b Antibody (A700-111) in IHC (P)
Detection of human CEACAM8/CD66b in FFPE lung carcinoma pleural effusion by immunohistochemistry. Antibody: Rabbit anti-CEACAM8/CD66b recombinant monoclonal antibody [BLR111H] (A700-111 Lot 1). Secondary: HRP-conjugated goat anti-rabbit IgG (A120-501P). Substrate: DAB.
产品信息
A700-111
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BLR111H
偶联物
形式
Liquid
浓度
250 µg/mL
纯化类型
purified
保存液
BBS, pH 8.2, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
靶标信息
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Carcinoembryonic antigen CGM6; carcinoembryonic antigen gene family member 6; Carcinoembryonic antigen-related cell adhesion molecule 8; CD66b; CD67 antigen; Non-specific cross-reacting antigen NCA-95
基因别名: CD66b; CD67; CEACAM8; CGM6; NCA-95
UniProt ID: (Human) P31997
Entrez Gene ID: (Human) 1088
