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产品信息
PA5-84987
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792136
产品详细信息
Immunogen sequence: QGHEELSRLS QYRKELGAQL HQLVLNSARE KRDMEQRHVL LKQKELGGEE PEPSLREGPG GLVMEGHLFK
靶标信息
ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
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生物信息学
蛋白别名: Arf GAP with coiled coil, ANK repeat and PH domains 1; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; centaurin beta 1; centaurin, beta 1; Centaurin-beta-1; Cnt-b1
基因别名: ACAP1; CENTB1; KIAA0050
UniProt ID: (Human) Q15027
Entrez Gene ID: (Human) 9744
