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产品信息
PA5-34486
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the amino terminus of human CHCHD6
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551838
产品详细信息
A suggested positive control is SK-N-SH cell lysate.
PA5-34486 can be used with blocking peptide PEP-1528.
靶标信息
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: coiled coil helix cristae morphology 1; coiled coil helix cristae morphology protein 1; coiled-coil-helix cristae morphology 1; Coiled-coil-helix cristae morphology protein 1; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; MICOS complex subunit MIC25; protein phosphatase 1, regulatory subunit 23
基因别名: CHCHD6; CHCM1; MIC25; PPP1R23
UniProt ID: (Human) Q9BRQ6
Entrez Gene ID: (Human) 84303
