Proteintech

CHRNA5 Monoclonal Antibody (3G8C11)

CHRNA5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CHRNA5 Antibody (66363-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human bladder tissue slide using 66363-1-IG ( CHRNA5 Antibody) at dilution of 1:200 (under 40x lens).

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产品信息

66363-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:4,000

查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

查看6篇已发表文章 6篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

产品规格

种属反应

Human, Mouse, Pig

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

3G8C11

抗原

CHRNA5 Fusion Protein Ag4447 (32-251 aa encoded by BC033639)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: GAQRGLSEP SSIAKHEDSL LKDLFQDYER WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK QEWIDVKLRW NPDDYGGIKV IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT VIRYNGTVTW TPPANYKSSC TIDVTFFPFD LQNCSMKFGS WTYDGSQVDI ILEDQDVDKR DFFDNGEWEI VSATGSKGNR TDSCCWYPYV TYSFVIKRLP L (32-251 aa encoded by BC033639)

靶标信息

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer.

Carcinogenesis

Zhang Q,Jia Y,Pan P,Zhang X,Jia Y,Zhu P,Chen X,Jiao Y,Kang G,Zhang L,Ma X

Thu May 19 00:00:00 EDT 2022

Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling.

Cell communication and signaling : CCS

Zhu P,Jin Z,Kang G,Jia Y,Liu D,Zhang Q,Guo F,Jia Y,Jiao Y,Li J,Sun H,Ma X

Mon Aug 15 00:00:00 EDT 2022

CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models.

The Journal of investigative dermatology

Wang J,Li X,Zhang P,Yang T,Liu N,Qin L,Ma G,Li X,Fan H,Huang S,Dang N

Tue Nov 01 00:00:00 EDT 2022

The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration.

Toxicology

Jia Y,Zhang Q,Liu Z,Pan P,Jia Y,Zhu P,Jiao Y,Kang G,Ma X

Tue Mar 15 00:00:00 EDT 2022

The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion.

Human cell

Zhu P,Kang G,Jiao Y,Gui C,Fan H,Li X,Jia Y,Zhang L,Ma X

Fri Jul 01 00:00:00 EDT 2022

生物信息学

蛋白别名: acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 5 (neuronal); cholinergic receptor; Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5; cholinergic receptor, nicotinic alpha 5; cholinergic receptor, nicotinic, alpha 5 (neuronal); nAChR alpha 5; Neuronal acetylcholine receptor subunit alpha-5; neuronal nicotinic acetylcholine receptor, alpha5 subunit; nicotinic acetylcholine receptor alpha5 subunit

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基因别名: Acra-5; Acra5; CHRNA5; LNCR2; NACHRA5

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UniProt ID: (Human) P30532, (Mouse) Q2MKA5

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Entrez Gene ID: (Pig) 100156023, (Human) 1138, (Mouse) 110835

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功能

acetylcholine-activated cation-selective channel activity protein binding ligand-gated ion channel activity acetylcholine receptor activity acetylcholine binding protein heterodimerization activity ion channel activity extracellular ligand-gated ion channel activity ligand-gated ion channel

参与通路

transport signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission behavioral response to nicotine cation transmembrane transport ion transport cation transport response to nicotine