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产品信息
PA5-36938
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 626-671 of human CLCNKA
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2553825
产品详细信息
This antibody detects endogenous protein at a molecular weight of 75 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter's syndrome which is characterized by renal salt-wasting and low blood pressure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chloride channel K1; Chloride channel Ka; Chloride channel protein ClC-Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; ClC-K1; CLC-KA; CLCKA
基因别名: ClC-K1; CLCK1; Clcnk1; CLCNKA; hClC-Ka
UniProt ID: (Human) P51800, (Rat) Q06393
Entrez Gene ID: (Human) 1187, (Rat) 79425
transport
excretion
ion transmembrane transport
chloride transmembrane transport
regulation of anion transmembrane transport
kidney development
chloride transport
body fluid secretion
response to pH
response to water deprivation
regulation of ion transmembrane transport
regulation of anion transport
regulation of body fluid levels
response to calcium ion
renal inner medulla development
