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产品信息
PA5-34928
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 218 of CLEC5A
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2552277
产品详细信息
Recommended positive controls: K562.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin domain family 5 member A; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL-1; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1; type II transmembrane protein MDL-1
基因别名: CLEC5A; CLECSF5; Ly100; MDL-1; MDL1
UniProt ID: (Human) Q9NY25, (Mouse) Q9R007
Entrez Gene ID: (Human) 23601, (Mouse) 23845
osteoblast development
cellular defense response
signal transduction
myeloid cell differentiation
negative regulation of myeloid cell apoptotic process
negative regulation of apoptotic process
innate immune response
viral entry into host cell
positive regulation of cytokine secretion
immune system process
