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CLEC7A/Dectin-1 (extracellular) Antibody (ALR-062-200UL) in IHC (F)
Multiplex staining of CLEC7A and GFAP in rat hippocampal CA1 region - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-CLEC7A/Dectin-1 (extracellular) Antibody (#ALR-062), (1:600), followed by goat Anti-rabbit-AlexaFluor-488 and Guinea Pig Anti-GFAP Antibody (#AFP-001-GP), (1:600), followed by goat Anti-guinea pig-AlexaFluor-594. A. CLEC7A immunoreactivity (green) appears ... View More
产品信息
ALR-062-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RNKENHKPTESSLDEK, corresponding to amino acid residues 87-102 of mouse CLEC7A, Extracellular, C-terminus
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta-glucan receptor; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; dectin-1; dendritic cell-associated C-type lectin 1
基因别名: beta-GR; BGR; Clec7b; Clecsf12; RGD1565140
Entrez Gene ID: (Mouse) 56644, (Rat) 502902
response to yeast
detection of yeast
pattern recognition receptor signaling pathway
response to molecule of fungal origin
leukocyte activation involved in immune response
immune system process
cell surface pattern recognition receptor signaling pathway
phagocytosis, recognition
phagocytosis, engulfment
inflammatory response
cell recognition
single organismal cell-cell adhesion
positive regulation of tumor necrosis factor production
innate immune response
positive regulation of phagocytosis
cellular response to molecule of fungal origin
