Proteintech

CLOCK Polyclonal Antibody

CLOCK Antibody in Immunocytochemistry (ICC/IF)

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CLOCK Antibody (18094-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 18094-1-AP (CLOCK antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CLOCK Antibody in Immunoprecipitation (IP)

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产品信息

18094-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看14篇已发表文章 14篇已发表文章

免疫组化 (IHC)

Assay-dependent

查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

1:20-1:200

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

CLOCK Fusion Protein Ag12826 (1-351 aa encoded by BC041878)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.13 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MLFTVSCSK MSSIVDRDDS SIFDGLVEED DKDKAKRVSR NKSEKKRRDQ FNVLIKELGS MLPGNARKMD KSTVLQKSID FLRKHKEITA QSDASEIRQD WKPTFISNEE FTQLMLEALD GFFLAIMTDG SIIYVSESVT SLLEHLPSDL VDQSIFNFIP EGEHSEVYKI LSTHLLESDS LTPEYLKSKN QLEFCCHMLR GTIDPKEPST YEYVKFIGNF KSLNSVSSSA HNGFEGTIQR THRPSYEDRV CFVATVRLAT PQFIKEMCTV EEPNEEFTSR HSLEWKFLFL DHRAPPIIGY LPFEVLGTSG YDYYHVDDLE NLAKCHEHLM QYGKGKSCYY RFLTKGQQWI WL (1-351 aa encoded by BC041878)

靶标信息

This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.

bioRxiv : the preprint server for biology

Hammarlund JA,Li SY,Wu G,Lian JW,Howell SJ,Clarke R,Adamson A,Gonçalves CF,Hogenesch JB,Meng QJ,Anafi RC

Fri May 19 00:00:00 EDT 2023

The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.

Nature communications

Wu J,Bu D,Wang H,Shen D,Chong D,Zhang T,Tao W,Zhao M,Zhao Y,Fang L,Li P,Xue B,Li CJ

Fri Mar 24 00:00:00 EDT 2023

Resveratrol reversed ambient particulate matter exposure-perturbed oscillations of hepatic glucose metabolism by regulating SIRT1 in mice.

Environmental science and pollution research international

Jiang J,Gu Y,Ding S,Zhang G,Ding J

Wed Mar 01 00:00:00 EST 2023

The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway.

The British journal of nutrition

Zhu X,Liu J,Cai M,Bao L,Pan Y,Wu P,Chu W,Zhang J

Mon Aug 28 00:00:00 EDT 2023

1,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Fan Y,Lu J,Fan J,Guan S

Sat Apr 01 00:00:00 EDT 2023

A druggable copper-signalling pathway that drives inflammation.

Nature

Solier S,Müller S,Cañeque T,Versini A,Mansart A,Sindikubwabo F,Baron L,Emam L,Gestraud P,Pantoș GD,Gandon V,Gaillet C,Wu TD,Dingli F,Loew D,Baulande S,Durand S,Sencio V,Robil C,Trottein F,Péricat D,Näser E,Cougoule C,Meunier E,Bègue AL,Salmon H,Manel N,Puisieux A,Watson S,Dawson MA,Servant N,Kroemer G,Annane D,Rodriguez R

Mon May 01 00:00:00 EDT 2023

Level of constitutively expressed BMAL1 affects the robustness of circadian oscillations.

Scientific reports

Padlom A,Ono D,Hamashima R,Furukawa Y,Yoshimura T,Nishiwaki-Ohkawa T

Mon Nov 14 00:00:00 EST 2022

Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.

Journal of agricultural and food chemistry

Li R,Xiao J,Cao Y,Huang Q,Ho CT,Lu M

Wed Jan 26 00:00:00 EST 2022

Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.

International journal of molecular sciences

Zhang W,Ho CT,Lu M

Tue May 17 00:00:00 EDT 2022

Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation.

Oncology reports

Jia M,Su B,Mo L,Qiu W,Ying J,Lin P,Yang B,Li D,Wang D,Xu L,Li H,Zhou Z,Li X,Li J

Mon Mar 01 00:00:00 EST 2021

hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.

Cell death & disease

Wan X,Zhu L,Zhao L,Peng L,Xiong J,Yang W,Yuan J,Liang F,Zhang K,Chen K

Fri Mar 19 00:00:00 EDT 2021

Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.

Journal of immunology research

Tan X,Cao F,Tang F,Lu C,Yu Q,Feng S,Yang Z,Chen S,He X,He J,Weng L,Sun L

Mon Dec 20 00:00:00 EST 2021

Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.

Journal of immunology research

Tan X,Cao F,Tang F,Lu C,Yu Q,Feng S,Yang Z,Chen S,He X,He J,Weng L,Sun L

Mon Dec 20 00:00:00 EST 2021

Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.

Journal of neurochemistry

Zhang L,Yang H,Zhang W,Liang Z,Huang Q,Xu G,Zhen X,Zheng LT

Tue Aug 01 00:00:00 EDT 2017

A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.

Neoplasia (New York, N.Y.)

Cui M,Zheng M,Sun B,Wang Y,Ye L,Zhang X

Thu Jan 01 00:00:00 EST 2015

A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.

Neoplasia (New York, N.Y.)

Cui M,Zheng M,Sun B,Wang Y,Ye L,Zhang X

Thu Jan 01 00:00:00 EST 2015

A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.

Neoplasia (New York, N.Y.)

Cui M,Zheng M,Sun B,Wang Y,Ye L,Zhang X

Thu Jan 01 00:00:00 EST 2015

A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.

Neoplasia (New York, N.Y.)

Cui M,Zheng M,Sun B,Wang Y,Ye L,Zhang X

Thu Jan 01 00:00:00 EST 2015

生物信息学

蛋白别名: bHLHe8; circadian locomoter output cycles kaput protein; Circadian locomoter output cycles protein kaput; Class E basic helix-loop-helix protein 8; clock homolog; hCLOCK

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基因别名: BHLHE8; CLOCK; KAT13D; KIAA0334

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UniProt ID: (Human) O15516

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Entrez Gene ID: (Human) 9575

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