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Invitrogen
CMKLR1 Recombinant Rabbit Monoclonal Antibody (7H10L22)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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CMKLR1 Antibody (703553) in ICC/IF
Knockdown of CMKLR1 was achieved by transfecting Hep G2 cells with specific siRNA (Silencer® select Product # s3226). Immunofluorescence analysis was performed on Hep G2 cells (untransfected, panel a-d), transfected with CMKLR1 specific siRNA (panel i-l) or non-specific scrambled siRNA (panels e-h). Cells were fixed, permeabilized, and labeled with Anti-CMKLR1 Recombinant Rabbit Monoclonal Antibody (Product # 703553, 1:100 dilution), followed by Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate ... View More
产品信息
703553
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7H10L22
抗原
Peptides corresponding to human CMKLR1 [1) aa11-aa24 2) aa360-aa373]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2784587
产品详细信息
This antibody is predicted to react with Monkey, Pig, Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chemerin receptor; Chemerin-like receptor 1; chemokine receptor-like 1; Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; orphan G-protein coupled receptor, Dez; resolvin E1 receptor
基因别名: CHEMERINR; CHEMR23; CMKLR1; DEZ; RVER1
UniProt ID: (Human) Q99788
Entrez Gene ID: (Human) 1240
skeletal system development
chemotaxis
immune response
G-protein coupled receptor signaling pathway
positive regulation of macrophage chemotaxis
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-12 production
positive regulation of fat cell differentiation
regulation of calcium-mediated signaling
chemokine-mediated signaling pathway
