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CNGA1 Antibody (PA5-101516) in ICC/IF
Immunofluorescent analysis of CNGA1 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CNGA1 polyclonal antibody (Product # PA5-101516) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-101516
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CNGA1(Accession P29973), corresponding to amino acid residues N404-L454.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2815891
产品详细信息
Antibody detects endogenous levels of total CNGA1.
靶标信息
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cGMP-gated cation channel alpha-1; cng channel; CNG channel alpha-1; CNG-1; CNG1; cyclic nucleotide gated channel, cGMP gated; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel, photoreceptor; interleukin-1 homologue; Rod photoreceptor cGMP-gated cation channel subunit alpha; rod photoreceptor cGMP-gated channel subunit alpha
基因别名: CNCG; CNCG1; CNG-1; CNG1; CNGA1; HCN; RCNC1; RCNCa; RCNCalpha; RP49
UniProt ID: (Human) P29973, (Mouse) P29974, (Rat) Q62927
Entrez Gene ID: (Human) 1259, (Mouse) 12788, (Rat) 85259
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
protein binding
cGMP binding
nucleotide binding
ion channel activity
intracellular cyclic nucleotide activated cation channel activity
ligand-gated ion channel
transport
visual perception
rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signaling pathway
regulation of membrane potential
potassium ion transmembrane transport
ion transport
regulation of ion transmembrane transport
response to stimulus
regulation of cytosolic calcium ion concentration
membrane depolarization
transmembrane transport
cation transmembrane transport
spermatogenesis
phototransduction, visible light
ion transmembrane transport
