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Predicted reactivity by homology: Xenopus tropicalis, Zebrafish.
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: adrenal gland protein AD-005; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 1; CCR4-NOT transcription complex, subunit 1; Negative regulator of transcription subunit 1 homolog; NOT1 (negative regulator of transcription 1, yeast) homolog; NOT1H
基因别名: 6030411K04Rik; AA815922; AD-005; CDC39; CNOT1; D830048B13; KIAA1007; NOT1; NOT1H
UniProt ID: (Human) A5YKK6, (Mouse) Q6ZQ08
Entrez Gene ID: (Human) 23019, (Mouse) 234594
分子生物学功能:
RNA metabolism protein
mRNA polyadenylation factor
RNA processing factor
nucleic acid metabolism protein