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产品信息
TA808695
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
OTI6D7
抗原
Full length human recombinant protein of human CNOT2 produced in E.coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CCR4-NOT Transcription Complex 2 (CNOT2) is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT2 is required for the CCR4-NOT complex structural integrity. It can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. CNOT2 is involved in the maintenance of embryonic stem (ES) cell identity. (UniProt)
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生物信息学
蛋白别名: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; negative regulator of transcription 2
基因别名: CDC36; CNOT2; HSPC131; MSTP046; NOT2; NOT2H
UniProt ID: (Human) Q9NZN8
Entrez Gene ID: (Human) 4848
negative regulation of transcription from RNA polymerase II promoter
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of cytoplasmic mRNA processing body assembly
negative regulation of translation
gene silencing by RNA
negative regulation of intracellular estrogen receptor signaling pathway
RNA phosphodiester bond hydrolysis, exonucleolytic
regulation of stem cell population maintenance
