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Immunogen sequence: MPAATVDHS QRICEVWACN LDEEMKKIRQ VIRKYNYVAM DTEFPGVVAR PIGEFRSNAD YQYQLLRCNV DLLKIIQLGL TFMNEQGEYP PGTSTWQFNF KFNLTEDMYA QDSIELLTTS GIQFKKHEEE GIETQYFAEL LMTSGVVLCE GVKWLSFHSG YDFGYLIKIL TNSNLPEEEL DFFEILRLFF PVIYDVKYLM KSCKNLKGGL QEVAEQLELE RIGPQHQAGS DSLLTGMAFF KMREMFFEDH IDDAKYCGHL YGLGSGSSYV QNGTGNAYEE EANKQS (1-285 aa encoded by B C060852)
CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation. During miRNA-mediated repression, the complex seems to act as a transcriptional repressor during translational initiation, as well. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT7 associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BTG1-binding factor 1; CAF-1; Caf1a; carbon catabolite repressor protein (CCR4)-associative factor 1; catabolite repressor protein (CCR4)-associative factor 1; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 7; POP2 homolog
基因别名: AU022737; CAF-1; CAF1; Caf1a; CNOT7; hCAF-1; Pop2
UniProt ID: (Human) Q9UIV1, (Mouse) Q60809
Entrez Gene ID: (Human) 29883, (Mouse) 18983, (Rat) 306492
分子生物学功能:
mRNA polyadenylation factor