Search Thermo Fisher Scientific
Immunogen sequence: AYQLAVEAES EQKWKQLAEL AISKCQFGLA QECLHHAQDY GGLLLLATAS GNANMVNKLA EGAERDGKNN VAFMSYFLQG KVDACLELLI RTGRLPEAAF LARTYLPSQV SRVVKLWREN LSKVNQKAAE SLADPTEYEN LFPGLKEAFV VEEWVKETHA DLWPAKQYPL VTPNEERNVM EEGKDFQPSR STAQQELDGK PASPTPVIVA SHTANKEEKS LLELEVDLDN LELEDIDTTD INLDEDILDD; Positive Samples: SW480, MCF7, HeLa, HepG2, Jurkat, Mouse liver, Mouse kidney, Mouse stomach; Cellular Location: COPI-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein, cytosol
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: beta prime COP; Beta'-coat protein; Beta'-COP; betaprime-COP; coatomer binding complex, beta prime subunit; coatomer protein complex subunit beta 2 (beta prime); coatomer protein complex subunit beta prime; coatomer protein complex, subunit beta 2 (beta prime); Coatomer subunit beta'; p102
基因别名: AI256832; beta'-COP; COPB2
UniProt ID: (Human) P35606, (Rat) O35142, (Mouse) O55029
Entrez Gene ID: (Human) 9276, (Rat) 60384, (Mouse) 50797