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产品信息
TA504344
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2B12
抗原
Full length human recombinant protein of human COPS5 produced in HEK293T cell.
偶联物
形式
Liquid
浓度
0.76 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
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生物信息学
蛋白别名: 38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; MGC3149; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
基因别名: COPS5; CSN5; JAB1; MOV-34; SGN5
UniProt ID: (Human) Q92905
Entrez Gene ID: (Human) 10987
protein deneddylation
nucleotide-excision repair, DNA damage recognition
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
translation
translational initiation
cullin deneddylation
protein deubiquitination
positive regulation of transcription from RNA polymerase II promoter
regulation of JNK cascade
regulation of cell cycle
regulation of IRE1-mediated unfolded protein response
exosomal secretion
