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COQ3 Antibody (PA5-121106) in ICC/IF
Immunofluorescence analysis of COQ3 in A549 cells. Samples were incubated with COQ3 Polyclonal antibody (Product # PA5-121106). Blue: DAPI for nuclear staining.
产品信息
PA5-121106
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 50-369 of human COQ3 (NP_059117.3).
偶联物
Unconjugated
形式
Liquid
浓度
0.74 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914678
产品详细信息
Positive test controls include: HeLa, NCI-H460, MCF7, Mouse liver, Mouse brain, Mouse heart, Mouse kidney, Rat liver. The target is usually found in the following locations: Matrix side, Mitochondrion inner membrane, Peripheral membrane protein.
Immunogen sequence: PGVFNEYRTI WFKSYRTIFS CLNRIKSFRY PWARLYSTSQ TTVDSGEVKT FLALAHKWWD EQGVYAPLHS MNDLRVPFIR DNLLKTIPNH QPGKPLLGMK ILDVGCGGGL LTEPLGRLGA SVIGIDPVDE NIKTAQCHKS FDPVLDKRIE YRVCSLEEIV EETAETFDAV VASEVVEHVI DLETFLQCCC QVLKPGGSLF ITTINKTQLS YALGIVFSEQ IASIVPKGTH TWEKFVSPET LESILESNGL SVQTVVGMLY NPFSGYWHWS ENTSLNYAAY AVKSRVQEHP ASAEFVLKGE TEELQANACT NPAVHEKLKK
靶标信息
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes. This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2-polyprenyl-6-hydroxyphenol methylase; 2-polyprenyl-6-hydroxyphenyl methylase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone-10 3-methyltransferase; 3-demethylubiquinone-9 3-methyltransferase; Coenzyme Q (ubiquinone); coenzyme Q3 homolog methyltransferase; coenzyme Q3 homolog, methyltransferase; coenzyme Q3 methyltransferase; DHHB methyltransferase; DHHB-MT; DHHB-MTase; dihydroxyhexaprenylbenzoate methyltransferase; hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; methyltransferase COQ3; Polyprenyldihydroxybenzoate methyltransferase; Ubiquinone biosynthesis O-methyltransferase, mitochondrial
基因别名: 4732433J24; bA9819.1; C77934; COQ3; DHHBMT; DHHBMTASE; UG0215E05
UniProt ID: (Human) Q9NZJ6, (Mouse) Q8BMS4, (Rat) Q63159
Entrez Gene ID: (Human) 51805, (Mouse) 230027, (Rat) 29309
hexaprenyldihydroxybenzoate methyltransferase activity
O-methyltransferase activity
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
3-demethylubiquinone-9 3-O-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
decaprenyldihydroxybenzoate methyltransferase activity
3-demethylubiquinone-10 3-O-methyltransferase activity
methyltransferase activity
transferase activity
methyltransferase
