Invitrogen

CREBRF Polyclonal Antibody

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CREBRF Antibody (PA5-68552) in WB

Western blot analysis of CREBRF on human lung cells. The sample was probed with a CREBRF polyclonal antibody (Product # PA5-68552) using a primary antibody dilution of 0.2-1.0 µg/mL.

CREBRF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-68552

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1.0 µg/mL

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免疫组化（石蜡） (IHC (P))

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产品规格

种属反应

Human

已发表种属

Human, Pig

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the middle region of human CREBRF

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2689327

产品详细信息

This target displays homology in the following species: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

靶标信息

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC.

Cancers

Shibata T,Cao DY,Dar TB,Ahmed F,Bhat SA,Veiras LC,Bernstein EA,Khan AA,Chaum M,Shiao SL,Tourtellotte WG,Giani JF,Bernstein KE,Cui X,Vail E,Khan Z

PA5-68552 was used in Western Blotting to demonstrate a novel miR124-3p- and miR766-3p-based biological mechanism governing treatment-resistant HNSCC, which can be targeted to improve clinical outcomes in HNSCC.

Thu Oct 27 00:00:00 EDT 2022

miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC.

Cancers

Shibata T,Cao DY,Dar TB,Ahmed F,Bhat SA,Veiras LC,Bernstein EA,Khan AA,Chaum M,Shiao SL,Tourtellotte WG,Giani JF,Bernstein KE,Cui X,Vail E,Khan Z

Thu Oct 27 00:00:00 EDT 2022

miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC.

Cancers

Shibata T,Cao DY,Dar TB,Ahmed F,Bhat SA,Veiras LC,Bernstein EA,Khan AA,Chaum M,Shiao SL,Tourtellotte WG,Giani JF,Bernstein KE,Cui X,Vail E,Khan Z

Thu Oct 27 00:00:00 EDT 2022

Generation of a genetically modified pig model with CREBRF^R457Q variant.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li Y,Wang H,Chen H,Liao Y,Gou S,Yan Q,Zhuang Z,Li H,Wang J,Suo Y,Lan T,Liu Y,Zhao Y,Zou Q,Nie T,Hui X,Lai L,Wu D,Fan N

PA5-68552 was used in Western Blotting to investigate the functional consequences of the CREBRF variant by introducing the corresponding human mutation R457Q into the porcine genome.

Tue Nov 01 00:00:00 EDT 2022

生物信息学

蛋白别名: adult retina protein; CREB3 regulatory factor; LRF; Luman recruitment factor; luman-recruiting factor; luman/CREB3 recruitment factor; UPF0474 protein C5orf41

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基因别名: C5orf41; CREBRF; LRF

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UniProt ID: (Human) B3KW49

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Entrez Gene ID: (Human) 153222

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功能

transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding

参与通路

transcription, DNA-templated regulation of transcription, DNA-templated transport response to unfolded protein maternal behavior negative regulation of glucocorticoid mediated signaling pathway positive regulation of prolactin signaling pathway