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CRH Monoclonal Antibody (2B11)

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抗体检测数据 (2)

CRH Antibody in Western Blot (WB)

CRH Antibody in Western Blot (WB)

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CRH Antibody (H00001392-M02) in WB

Western Blot analysis of CRH expression in transfected 293T cell line by CRH monoclonal antibody (M02), clone 2B11.

Lane 1: CRH transfected lysate(21.4 KDa).
Lane 2: Non-transfected lysate.

CRH Antibody in Western Blot (WB)

CRH Antibody in ELISA (ELISA)

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CRH Antibody in Western Blot (WB) — Western Blot analysis of CRH expression in transfected 293T cell line by CRH monoclonal antibody (M02), clone 2B11.

Lane 1: CRH transfected lysate(21.4 KDa).
Lane 2: Non-transfected lysate.

CRH Antibody in ELISA (ELISA) — Detection limit for recombinant GST tagged CRH is 0.3 ng/mL as a capture antibody.

产品信息

H00001392-M02

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

酶联免疫吸附实验 (ELISA)

0.3 ng/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

2B11

抗原

CRH (AAH11031, 154 a.a. approximately 196 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: SEEPPISLDL TFHLLREVLE MARAEQLAQQ AHSNRKLMEI IGK

靶标信息

Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Corticoliberin; Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF

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基因别名: CRF; CRH; CRH1

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UniProt ID: (Human) P06850

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Entrez Gene ID: (Human) 1392

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receptor binding hormone activity neuropeptide hormone activity protein binding corticotropin-releasing hormone activity corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding peptide hormone

参与通路

positive regulation of protein phosphorylation synaptic transmission, dopaminergic glucocorticoid biosynthetic process inflammatory response signal transduction chemical synaptic transmission female pregnancy parturition learning or memory positive regulation of cell proliferation associative learning hormone-mediated apoptotic signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of norepinephrine secretion positive regulation of circadian sleep/wake cycle, wakefulness positive regulation of cell death regulation of serotonin secretion diterpenoid metabolic process hypothalamus development lung development adrenal gland development positive regulation of cAMP biosynthetic process negative regulation of epinephrine secretion negative regulation of luteinizing hormone secretion locomotory exploration behavior positive regulation of insulin secretion involved in cellular response to glucose stimulus response to immobilization stress negative regulation of circadian sleep/wake cycle, REM sleep response to drug response to estrogen response to ethanol response to ether negative regulation of blood pressure response to pain ion homeostasis response to corticosterone positive regulation of corticotropin secretion positive regulation of cortisol secretion long-term synaptic potentiation positive regulation of digestive system process negative regulation of cell death negative regulation of glucagon secretion cellular response to cocaine cellular response to dexamethasone stimulus positive regulation of calcium ion import regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of corticosterone secretion positive regulation of behavioral fear response