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产品信息
CRMP1-101AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to 80-130 on CRMP1 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
靶标信息
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
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生物信息学
蛋白别名: Collapsin response mediator protein 1; CRMP-1; dihydropyrimidinase-like 1; Dihydropyrimidinase-related protein 1; DRP-1; Inactive dihydropyrimidinase; ULIP-3; Unc-33-like phosphoprotein 3
基因别名: CRMP-1; CRMP1; DPYSL1; DRP-1; DRP1; ULIP-3; ULIP3
UniProt ID: (Human) Q14194, (Mouse) P97427
Entrez Gene ID: (Human) 1400, (Mouse) 12933
