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产品信息
TA803799
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI5D4
抗原
Human recombinant protein fragment corresponding to amino acids 153-416 of human CSNK1E produced in E.coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CSNK1E (CK1 epsilon) is a serine/threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis. CSNK1E phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: casein kinase 1; casein kinase 1, epsilon; Casein kinase I isoform epsilon; CK1e; CKI-epsilon; CKIe; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1
基因别名: CKIepsilon; CSNK1E; HCKIE
UniProt ID: (Human) P49674
Entrez Gene ID: (Human) 1454
G2/M transition of mitotic cell cycle
DNA repair
rRNA processing
protein phosphorylation
endocytosis
signal transduction
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
negative regulation of Wnt signaling pathway
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
circadian regulation of gene expression
cellular protein localization
regulation of circadian rhythm
positive regulation of canonical Wnt signaling pathway
regulation of cellular protein localization
positive regulation of dopaminergic neuron differentiation
positive regulation of non-canonical Wnt signaling pathway
