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产品信息
10606-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CSNK2A2 Fusion Protein Ag0877 (50-350 aa encoded by BC008812)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: KYSEVFEAI NITNNERVVV KILKPVKKKK IKREVKILEN LRGGTNIIKL IDTVKDPVSK TPALVFEYIN NTDFKQLYQI LTDFDIRFYM YELLKALDYC HSKGIMHRDV KPHNVMIDHQ QKKLRLIDWG LAEFYHPAQE YNVRVASRYF KGPELLVDYQ MYDYSLDMWS LGCMLASMIF RREPFFHGQD NYDQLVRIAK VLGTEELYGY LKKYHIDLDP HFNDILGQHS RKRWENFIHS ENRHLVSPEA LDLLDKLLRY DHQQRLTAKE AMEHPYFYPV VKEQSQPCAD NAVLSSGLTA AR (50-350 aa encoded by BC008812)
靶标信息
Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: casein kinase 2 alpha; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide; Casein kinase II subunit alpha'; CK II alpha'
基因别名: CK2A2; CK2alpha'; CSNK2A1; CSNK2A2
UniProt ID: (Human) P19784
Entrez Gene ID: (Human) 1459
transcription, DNA-templated
regulation of transcription, DNA-templated
protein folding
protein phosphorylation
apoptotic process
Wnt signaling pathway
mitotic spindle checkpoint
regulation of signal transduction by p53 class mediator
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
