Bethyl Laboratories

CTHRC1 Polyclonal Antibody

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CTHRC1 Antibody (A305-862A) in WB

Detection of human CTHRC1 by western blot. Samples: Whole cell lysate (50 µg) from UACC-62, Malme-3M, SR, and HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified Rabbit anti-CTHRC1 antibody (A305-862A lot 1) used for WB at 0.04 mg/mL. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-101P). Detection: Chemiluminescence with an exposure time of 10 seconds.

CTHRC1 Antibody in Immunoprecipitation (IP)

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产品信息

A305-862A

应用

建议稀释比

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免疫印迹 (WB)

1:10,000-1:25,000

免疫沉淀 (IP)

50-100 µL/mg of lysate

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A region between residue 25 and 75 of human Collagen triple helix repeat-containing protein 1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

phosphate, tris citrate

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration. CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.

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