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CTLA-4 (CD152) Antibody (PA5-79090) in IHC (P)
Immunohistochemistry analysis of CTLA-4 (CD152) on paraffin-embedded rat lymphaden tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with CTLA-4 (CD152) polyclonal antibody (Product# PA5-79090) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minute... View More
产品信息
PA5-79090
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse CTLA4 recombinant protein (Position: E36-D161).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746206
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD152; CD152 antigen; CTLA-4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; ICOS; soluble form; transmembrane form
基因别名: Cd152; CTLA-4; Ctla4; Ly-56; sCTLA4
UniProt ID: (Mouse) P09793
Entrez Gene ID: (Mouse) 12477, (Rat) 63835
immune system process
immune response
cellular response to DNA damage stimulus
negative regulation of B cell proliferation
negative regulation of T cell proliferation
positive regulation of apoptotic process
negative regulation of regulatory T cell differentiation
negative regulation of immune response
B cell receptor signaling pathway
