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Invitrogen

CXCL13 Polyclonal Antibody

6个已发表图片

5 篇参考文献

查看其他20个CXCL13抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (7)
已发表图片 (6)

Application

CXCL13 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 13

CXCL13 Antibody (PA5-28827) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of CXCL13 was performed in HepG2 cells fixed in 4% paraformaldehyde at RT for 15 min. Green: CXCL13 Polyclonal Antibody (Product # PA5-28827) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.

CXCL13 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CXCL13 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

产品信息

PA5-28827

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:10,000

查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫组化（冰冻） (IHC (F))

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:100-1:1,000

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to a region within amino acids 45 and 109 of Human BCA1

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

1.21 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2546303

产品详细信息

Recommended positive controls: CXCL13-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

CXCL13, also known as BCA-1 and Angie, is a small chemokine strongly expressed in the secondary lymphoid organs. It preferentially promotes the migration of B lymphocytes (both B-1 and B-2) to the follicles of the spleen, lymph nodes, and Peyer's patches. It is produced by macrophages, and in mouse the highest constitutive producers include large peritoneal macrophages, Kuppfer cells and lung macrophages (both CD11c+ and CD11c-). The cellular ligand for CXCL13 is CXCR5 also known as BLR-1 (Burkitt’s Lymphoma Receptor 1). CXCR5 is expressed on B cells, Tfh cells and, to a lower degree, some memory T cell populations. CXCL13 plays an important role in the development of chronic lymphocytic leukemia (CCL). CXCL13 is also a plasma biomarker for germinal center activity and generation of broadly neutralizing antibodies against HIV.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Single-cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer.

Immunology

Xia J,Xie Z,Niu G,Lu Z,Wang Z,Xing Y,Ren J,Hu Z,Hong R,Cao Z,Han S,Chu Y,Liu R,Ke C

Published figure using CXCL13 polyclonal antibody (Product # PA5-28827) in Immunohistochemistry

Sun Jan 01 00:00:00 UTC 2023

CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn.

Journal of neuroinflammation

Wang J,Yin C,Pan Y,Yang Y,Li W,Ni H,Liu B,Nie H,Xu R,Wei H,Zhang Y,Li Y,Hu Q,Tai Y,Shao X,Fang J,Liu B

PA5-28827 was used in Immunohistochemistry (Frozen) to demonstrate a previously unidentified role of CXCL13/CXCR5 signaling in mediating spinal neuroinflammation and mechanical pain in an animal model of CRPS-I. Our work suggests that targeting CXCL13/CXCR5 pathway may lead to novel therapeutic approaches for CRPS-I. © 2023.

Mon May 08 00:00:00 UTC 2023

CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn.

Journal of neuroinflammation

Wang J,Yin C,Pan Y,Yang Y,Li W,Ni H,Liu B,Nie H,Xu R,Wei H,Zhang Y,Li Y,Hu Q,Tai Y,Shao X,Fang J,Liu B

Mon May 08 00:00:00 UTC 2023

CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn.

Journal of neuroinflammation

Wang J,Yin C,Pan Y,Yang Y,Li W,Ni H,Liu B,Nie H,Xu R,Wei H,Zhang Y,Li Y,Hu Q,Tai Y,Shao X,Fang J,Liu B

Mon May 08 00:00:00 UTC 2023

Associations of C-X-C motif chemokine ligands 1/2/8/13/14 with clinicopathological features and survival profile in patients with colorectal cancer.

Oncology letters

Luo X,Tai J,Zhao Y,Zhao P,Sun D,Wang L

PA5-28827 was used in Immunohistochemistry to assess the correlation of C-X-C motif chemokine ligand (CXCL)1, CXCL2, CXCL8, CXCL13 and CXCL14 with clinicopathological features and survival profile in patients with colorectal cancer (CRC).

Sat Oct 01 00:00:00 UTC 2022

Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients.

Oncoimmunology

Jin K,Cao Y,Gu Y,Fang H,Fei Y,Wang J,Liu X,Lv K,He X,Lin C,Liu H,Li H,He H,Li R,Zhang H,Xu J

PA5-28827 was used in Immunohistochemistry to demonstrate that intratumoral CXCL13+CD8+ T cells infiltration could be an independent prognostic and predictive marker for gastric cancer patients, and might be a potential immunotherapeutic target in gastric cancer.

Tue Apr 27 00:00:00 UTC 2021

Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients.

Oncoimmunology

Jin K,Cao Y,Gu Y,Fang H,Fei Y,Wang J,Liu X,Lv K,He X,Lin C,Liu H,Li H,He H,Li R,Zhang H,Xu J

Tue Apr 27 00:00:00 UTC 2021

生物信息学

蛋白别名: Angie; B cell-attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); B-lymphocyte chemoattractant; BCA-1; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 13; CC motif chemokine; CCmotif chemokine; chem; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); CXC; CXC chemokine BLC; CXC motif chemokine; CXC motif chemokine 13; CXCL; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); Small-inducible cytokine B13

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基因别名: ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; CXCL13; SCYB13

UniProt ID: (Human) O43927

Entrez Gene ID: (Human) 10563

功能

chemokine activity heparin binding fibroblast growth factor binding CXCR5 chemokine receptor binding CCR10 chemokine receptor binding protein heterodimerization activity receptor agonist activity CXCR3 chemokine receptor binding chemokine

参与通路

germinal center formation lymphocyte chemotaxis across high endothelial venule chronic inflammatory response regulation of humoral immune response inflammatory response immune response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling positive regulation of T cell chemotaxis response to lipopolysaccharide positive regulation of integrin activation positive regulation of cell-cell adhesion mediated by integrin B cell chemotaxis endothelial cell chemotaxis to fibroblast growth factor B cell chemotaxis across high endothelial venule regulation of cell proliferation defense response to bacterium regulation of angiogenesis lymph node development chemokine-mediated signaling pathway activation of GTPase activity negative regulation of endothelial cell chemotaxis to fibroblast growth factor

CXCL13 Polyclonal Antibody

CXCL13 Antibody (PA5-28827) in ICC/IF

产品信息

PA5-28827

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫组化（冰冻） (IHC (F))

免疫细胞化学 (ICC/IF)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

CXCL13 Polyclonal Antibody

CXCL13 Antibody (PA5-28827) in ICC/IF

产品信息

PA5-28827

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫组化（冰冻） (IHC (F))

免疫细胞化学 (ICC/IF)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;}

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

RRID