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CXCR3 (CD183) Antibody (600-020) in IHC (P)
Immunohistochemistry: Human Tonsil (FFPE) stained with Mouse anti-CXCR3 (Cat# 600-020) at 1:500 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
产品信息
600-020
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1C6
抗原
A 37aa-synthetic peptide corresponding to the N-terminus of human CXCR3 conjugated to KLH
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with proprietary stabilizer
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Positive control: Transfected CXCR3 Cells
Cellular location: Cell Membrane.
靶标信息
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: an; C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 3; CC motif chemokine; CCmotif chemokine; CD183; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; CKR-L2; CXC; CXC motif chemokine; CXC-R3; CXCR-3; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 receptor; Mig receptor
基因别名: CD182; CD183; CKR-L2; CMKAR3; CXCR3; GPR9; IP10-R; Mig-R; MigR
UniProt ID: (Human) P49682, (Mouse) O88410, (Rat) Q9JII9
Entrez Gene ID: (Human) 2833, (Mouse) 12766, (Rat) 84475
angiogenesis
regulation of leukocyte migration
apoptotic process
movement of cell or subcellular component
chemotaxis
inflammatory response
cell adhesion
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
T cell chemotaxis
calcium-mediated signaling
chemokine-mediated signaling pathway
negative regulation of endothelial cell proliferation
positive regulation of cell proliferation
negative regulation of angiogenesis
sensory perception of pain
positive regulation of cAMP metabolic process
positive regulation of cAMP-mediated signaling
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of chemotaxis
positive regulation of release of sequestered calcium ion into cytosol
chemokine (C-C motif) ligand 11 production
negative regulation of execution phase of apoptosis
positive regulation of execution phase of apoptosis
