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产品信息
MA5-46977
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1260
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CYLD. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938049
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; FLJ20180; FLJ31664; FLJ78684; probable ubiquitin carboxyl-terminal hydrolase CYLD; retinitis pigmentosa 1 homolog; Ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD
基因别名: 2010013M14Rik; 2900009M21Rik; BRSS; C130039D01Rik; CDMT; CYLD; CYLD1; CYLDI; EAC; HSPC057; KIAA0849; LRRGT00003; MFT; MFT1; mKIAA0849; Rp1; Rp1h; SBS; TEM; USPL2
UniProt ID: (Human) Q9NQC7, (Rat) Q66H62, (Mouse) Q80TQ2
Entrez Gene ID: (Human) 1540, (Rat) 312937, (Mouse) 74256
thiol-dependent ubiquitin-specific protease activity
protein binding
zinc ion binding
protein kinase binding
Lys63-specific deubiquitinase activity
proline-rich region binding
molecular_function
structural constituent of ribosome
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
metal ion binding
ribosomal protein
ubiquitin-dependent protein catabolic process
cell cycle
regulation of mitotic cell cycle
regulation of tumor necrosis factor-mediated signaling pathway
Wnt signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
negative regulation of NF-kappaB import into nucleus
negative regulation of T cell differentiation
necroptotic process
nucleotide-binding oligomerization domain containing signaling pathway
regulation of microtubule cytoskeleton organization
protein K63-linked deubiquitination
negative regulation of canonical Wnt signaling pathway
ripoptosome assembly involved in necroptotic process
regulation of cilium assembly
positive regulation of extrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway
cytoplasmic translation
biological_process
protein deubiquitination
proteolysis
