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产品信息
PA5-99805
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CYP11B2(Accession P19099), corresponding to amino acid residues M309-T359.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2818738
产品详细信息
Antibody detects endogenous levels of total Cytochrome P450 11B2.
靶标信息
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYPXIB2; CYPXIB3; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily 11B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; Cytochrome P450C11; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P-450C 18; P450-Aldo-1; P450-Aldo-2; P450C 18; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; steroid-11-beta-hydroxylase
基因别名: ALDOS; Cp45as; CPN2; CYP11B; Cyp11b-2; CYP11B2; Cyp11b3; CYP11BL; CYPXIB2; P-450C18; P450aldo; P450C18; RNCP45AS
UniProt ID: (Human) P19099, (Mouse) P15539
Entrez Gene ID: (Human) 1585, (Mouse) 13072, (Rat) 24294
steroid 11-beta-monooxygenase activity
iron ion binding
steroid hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
heme binding
corticosterone 18-monooxygenase activity
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
metal ion binding
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
regulation of blood volume by renal aldosterone
steroid biosynthetic process
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
regulation of blood pressure
aldosterone biosynthetic process
cortisol biosynthetic process
drinking behavior
positive regulation of blood pressure
ion homeostasis
oxidation-reduction process
response to nutrient
response to salt stress
cellular response to nutrient
response to insulin
cellular response to hormone stimulus
cellular response to potassium ion
response to drug
response to peptide hormone
cellular response to potassium ion starvation
potassium ion homeostasis
sodium ion homeostasis
cellular response to mechanical stimulus
cellular response to peptide hormone stimulus
renal water homeostasis
mineralocorticoid biosynthetic process
cholesterol metabolic process
sterol metabolic process
secondary metabolite biosynthetic process
