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产品信息
TA501156
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
OTI15E2
抗原
Full length human recombinant protein of human CYP1A2 produced in HEK293T cell.
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aryl hydrocarbon hydroxylase; Cholesterol 25-hydroxylase; CYP; CYPIA2; Cytochrome P(3)450; Cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; Cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P(3)450; P450; P450 4; P450 form 4; P450-P3; xenobiotic monooxygenase
基因别名: CP12; CYP1A2; P3-450; P450(PA)
UniProt ID: (Human) P05177
Entrez Gene ID: (Human) 1544
monooxygenase activity
iron ion binding
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
enzyme binding
heme binding
demethylase activity
caffeine oxidase activity
aromatase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
steroid catabolic process
porphyrin-containing compound metabolic process
xenobiotic metabolic process
toxin biosynthetic process
post-embryonic development
alkaloid metabolic process
regulation of gene expression
monoterpenoid metabolic process
drug metabolic process
dibenzo-p-dioxin metabolic process
epoxygenase P450 pathway
lung development
methylation
response to estradiol
response to lipopolysaccharide
monocarboxylic acid metabolic process
response to immobilization stress
drug catabolic process
exogenous drug catabolic process
cellular respiration
heterocycle metabolic process
hydrogen peroxide biosynthetic process
oxidation-reduction process
oxidative demethylation
cellular response to cadmium ion
oxidative deethylation
omega-hydroxylase P450 pathway
