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Invitrogen
CYP2D6 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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CYP2D6 Antibody (PA5-83766)
Relative expression in different tissues in IHC: Detection of differential expression levels of CYP2D6 demonstrates antibody specificity. Immunohistochemical analysis of CYP2D6 using anti-CYP2D6 Polyclonal Antibody (Product #PA5-83766), shows significant staining of CYP2D6 in small intestine and shows minimal or weak staining in pancreas tissues. The relative expression levels of CYP2D6 within each tissue ... View More
产品信息
PA5-83766
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2790918
产品详细信息
Immunogen sequence: EYDDPRFLRL LDLAQEGLKE ESGFLREVLN AVPVLLHIPA LAGKVLRFQK AFLTQLDELL TEHRMTWDPA QPPRDLTE
靶标信息
Cytochrome p450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cholesterol 25-hydroxylase; CYPIID6; Cytochrome P450 2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; microsomal monooxygenase; nonfunctional cytochrome P450 2D6; xenobiotic monooxygenase
基因别名: CPD6; CYP2D; CYP2D6; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1
UniProt ID: (Human) P10635
Entrez Gene ID: (Human) 1565
monooxygenase activity
iron ion binding
drug binding
arachidonic acid epoxygenase activity
steroid hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
heme binding
aromatase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
xenobiotic metabolic process
steroid metabolic process
coumarin metabolic process
alkaloid metabolic process
alkaloid catabolic process
monoterpenoid metabolic process
drug metabolic process
arachidonic acid metabolic process
isoquinoline alkaloid metabolic process
drug catabolic process
heterocycle metabolic process
negative regulation of binding
oxidation-reduction process
oxidative demethylation
negative regulation of cellular organofluorine metabolic process
