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Invitrogen
CYP3A4 Polyclonal Antibody
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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CYP3A4 Antibody (PA5-14896) in IHC (P)
Immunohistochemistry analysis of CYP3A4 in formalin fixed and paraffin embedded human liver tissue. Samples were incubated with CYP3A4 polyclonal antibody (Product # PA5-14896) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
产品信息
PA5-14896
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 228-255 amino acids from the central region of human CYP3A4
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2090334
靶标信息
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; Cholesterol 25-hydroxylase; CYP; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 3A4; Cytochrome P450 HLp; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; Cytochrome P450-PCN1; glucocorticoid-inducible P450; MGC126680; Nifedipine oxidase; P450; P450-III, steroid inducible; P450-PCN1; Quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase
基因别名: CP33; CP34; CYP3A; CYP3A3; CYP3A4; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1
UniProt ID: (Human) P08684
Entrez Gene ID: (Human) 1576
monooxygenase activity
steroid binding
iron ion binding
steroid hydroxylase activity
oxidoreductase activity
oxygen binding
enzyme binding
heme binding
vitamin D3 25-hydroxylase activity
taurochenodeoxycholate 6alpha-hydroxylase activity
caffeine oxidase activity
albendazole monooxygenase activity
quinine 3-monooxygenase activity
testosterone 6-beta-hydroxylase activity
aromatase activity
vitamin D 24-hydroxylase activity
oxygenase
lipid metabolic process
steroid catabolic process
xenobiotic metabolic process
steroid metabolic process
androgen metabolic process
alkaloid catabolic process
monoterpenoid metabolic process
drug metabolic process
calcitriol biosynthetic process from calciol
vitamin D metabolic process
drug catabolic process
exogenous drug catabolic process
heterocycle metabolic process
oxidation-reduction process
oxidative demethylation
