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Proteintech

CYP46A1 Polyclonal Antibody

10 篇参考文献

查看其他9个CYP46A1抗体

说明书

实验方案

技术支持

货号 12486-1-AP

此产品在中国无法购买

150 µL

说明书

实验方案

技术支持

抗体检测数据 (9)

Application

CYP46A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 9

CYP46A1 Antibody (12486-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 12486-1-AP) (CYP46A1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CYP46A1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

产品信息

12486-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看6篇已发表文章 6篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

查看3篇已发表文章 3篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

CYP46A1 Fusion Protein Ag3116 (201-500 aa encoded by BC022539)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.28 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: TSMLLGAQK PLSQAVKLML EGITASRNTL AKFLPGKRKQ LREVRESIRF LRQVGRDWVQ RRREALKRGE EVPADILTQI LKAEEGAQDD EGLLDNFVTF FIAGHETSAN HLAFTVMELS RQPEIVARLQ AEVDEVIGSK RYLDFEDLGR LQYLSQVLKE SLRLYPPAWG TFRLLEEETL IDGVRVPGNT PLLFSTYVMG RMDTYFEDPL TFNPDRFGPG APKPRFTYFP FSLGHRSCIG QQFAQMEVKV VMAKLLQRLE FRLVPGQRFG LQEQATLKPL DPVLCTLRPR GWQPAPPPPP C (201-500 aa encoded by BC022539)

靶标信息

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Cholesterol-24-hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes.

The Journal of comparative neurology

Cataldi GG,Elorza SD,Toledano-Zaragoza A,de Olmos S,Cragnolini AB,Martín MG

Wed Feb 01 00:00:00 UTC 2023

The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet.

Food & nutrition research

Zhou F,Yang L,Sun W,Wang X,Guo N,Ma H,Yang L

Fri Feb 17 00:00:00 UTC 2023

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

Nature communications

Zhao Y,Hu D,Wang R,Sun X,Ropelewski P,Hubler Z,Lundberg K,Wang Q,Adams DJ,Xu R,Qi X

Wed Mar 02 00:00:00 UTC 2022

Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.

The Journal of steroid biochemistry and molecular biology

Kosaka S,Miyashita M,McNamala K,Nomura M,Shima H,Kawai M,Sato I,Harada-Shoji N,Ishida T,Choi MH,Sasano H

Fri Jul 01 00:00:00 UTC 2022

Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Shinohara Y,Ando H,Maekawa M,Arai M,Horibata Y,Satou M,Jojima T,Usui I,Aso Y,Sugimoto H

Wed Jun 01 00:00:00 UTC 2022

Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma.

Oncogene

Yang R,Zhao Y,Gu Y,Yang Y,Gao X,Yuan Y,Xiao L,Zhang J,Sun C,Yang H,Qin J,Li J,Zhang F,Zhang L,Ye J

Thu Oct 01 00:00:00 UTC 2020

NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.

EMBO reports

Mitroi DN,Pereyra-Gómez G,Soto-Huelin B,Senovilla F,Kobayashi T,Esteban JA,Ledesma MD

Tue Nov 05 00:00:00 UTC 2019

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.

Scientific reports

Ishikawa M,Yoshitomi T,Zorumski CF,Izumi Y

Thu Sep 22 00:00:00 UTC 2016

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.

Scientific reports

Ishikawa M,Yoshitomi T,Zorumski CF,Izumi Y

Thu Sep 22 00:00:00 UTC 2016

H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.

Neurobiology of aging

Ali-Rahmani F,Grigson PS,Lee S,Neely E,Connor JR,Schengrund CL

Sun Jun 01 00:00:00 UTC 2014

H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.

Neurobiology of aging

Ali-Rahmani F,Grigson PS,Lee S,Neely E,Connor JR,Schengrund CL

Sun Jun 01 00:00:00 UTC 2014

Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.

Journal of cellular biochemistry

Zhou M,Li P,Tan L,Qu S,Ying QL,Song H

Mon Feb 15 00:00:00 UTC 2010

Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.

Journal of cellular biochemistry

Zhou M,Li P,Tan L,Qu S,Ying QL,Song H

Mon Feb 15 00:00:00 UTC 2010

生物信息学

蛋白别名: CH24H; Cholesterol 24-hydroxylase; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; cholestrol 24-hydroxylase; Cytochrome P450 46A1; cytochrome P450, 46 (cholesterol 24-hydroxylase); cytochrome P450, 46a1 (cholesterol 24-hydroxylase); cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)

基因别名: CP46; CYP46; CYP46A1

UniProt ID: (Human) Q9Y6A2, (Mouse) Q9WVK8

Entrez Gene ID: (Human) 10858, (Rat) 362782, (Mouse) 13116

功能

iron ion binding steroid hydroxylase activity heme binding cholesterol 24-hydroxylase activity monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding oxidoreductase oxygenase metabolite interconversion enzyme

参与通路

bile acid biosynthetic process cholesterol catabolic process xenobiotic metabolic process nervous system development sterol metabolic process oxidation-reduction process lipid metabolic process steroid metabolic process cholesterol metabolic process