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CYP7B1 Antibody (PA5-75380) in IHC (P)
Immunohistochemistry analysis of CYP7B1 in paraffin-embedded human breast carcinoma tissue (strong membranous and cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with CYP7B1 polyclonal antibody (Product # PA5-75380) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
产品信息
PA5-75380
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 101-150 of Human CYP7B1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719108
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; Cytochrome P450 7B1; cytochrome P450, 7b1; cytochrome P450, subfamily 7B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; HCT-1; Hippocampal transcript 1 protein; Oxysterol 7-alpha-hydroxylase
基因别名: AW261589; CBAS3; CP7B; CYP7B1; D3Ertd552e; hct-1; SPG5A
UniProt ID: (Human) O75881, (Mouse) Q60991, (Rat) Q63688
Entrez Gene ID: (Human) 9420, (Mouse) 13123, (Rat) 25429
bile acid biosynthetic process
cholesterol metabolic process
sterol metabolic process
negative regulation of intracellular estrogen receptor signaling pathway
B cell chemotaxis
positive regulation of epithelial cell proliferation
oxidation-reduction process
prostate gland epithelium morphogenesis
lipid metabolic process
digestion
memory
circadian rhythm
steroid metabolic process
response to drug
response to cAMP
