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产品信息
PA5-22763
产品规格
种属反应
Human,
Mouse,
Rabbit
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide made to the human CYR61 protein sequence (between residues 150-250).
偶联物
激发/发射光谱
651/673 nm
查看光谱
形式
Liquid
浓度
0.58 mg/mL
纯化类型
Antigen affinity chromatography
保存液
50mM sodium borate
内含物
no preservative
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152181
产品详细信息
This antibody is predicted to react with rat and mouse based on 88% sequence homology.
靶标信息
CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3CH61; CCN family member 1; Cellular communication network factor 1; cysteine rich angiogenic inducer 61; Cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; IBP-10; IGF-binding protein 10; IGFBP-10; insulin-like growth factor binding protein 10; Insulin-like growth factor-binding protein 10; intermediate early; Protein CYR61; Protein GIG1
基因别名: AI325051; CCN1; CYR61; GIG1; IGFBP10
UniProt ID: (Human) O00622, (Mouse) P18406
Entrez Gene ID: (Rabbit) 100339657, (Human) 3491, (Mouse) 16007
regulation of cell growth
osteoblast differentiation
positive regulation of protein phosphorylation
intussusceptive angiogenesis
atrioventricular valve morphogenesis
apoptotic process involved in heart morphogenesis
ventricular septum development
chemotaxis
cell adhesion
cell-cell signaling
cell proliferation
anatomical structure morphogenesis
positive regulation of phospholipase activity
positive regulation of cell-substrate adhesion
extracellular matrix organization
positive regulation of cell migration
positive regulation of BMP signaling pathway
positive regulation of osteoblast proliferation
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
wound healing, spreading of cells
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
atrial septum morphogenesis
negative regulation of cell death
chondroblast differentiation
chorio-allantoic fusion
labyrinthine layer blood vessel development
positive regulation of cartilage development
regulation of ERK1 and ERK2 cascade
reactive oxygen species metabolic process
positive regulation of ceramide biosynthetic process
signal transduction
single organismal cell-cell adhesion
positive regulation of apoptotic process
positive regulation of cell differentiation
