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产品信息
PA5-81535
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the center region of the Mouse PPP3CA
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788739
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse Calcineurin A/PPP3CA.
靶标信息
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcineurin A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; Protein phosphatase 3 catalytic subunit alpha; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
基因别名: 2900074D19Rik; Caln; Calna; CN; CnA; Ppp3ca
UniProt ID: (Mouse) P63328
Entrez Gene ID: (Mouse) 19055
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
calcium-dependent protein serine/threonine phosphatase activity
protein binding
calmodulin binding
drug binding
hydrolase activity
enzyme binding
calmodulin-dependent protein phosphatase activity
metal ion binding
protein heterodimerization activity
protein dimerization activity
protein phosphatase
G1/S transition of mitotic cell cycle
protein dephosphorylation
protein import into nucleus
calcium ion transport
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
dephosphorylation
calcium-mediated signaling
calcineurin-NFAT signaling cascade
multicellular organismal response to stress
negative regulation of chromatin binding
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
skeletal muscle fiber development
negative regulation of dendrite morphogenesis
modulation of synaptic transmission
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NFAT protein import into nucleus
response to calcium ion
excitatory postsynaptic potential
cellular response to glucose stimulus
positive regulation of cardiac muscle hypertrophy in response to stress
