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The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: C1A/C1B; Calcitonin receptor; COPT1; CT receptor; CT-R; hCTR1
基因别名: Calcr; Clr
UniProt ID: (Rat) P32214, (Mouse) Q60755
Entrez Gene ID: (Rat) 116506, (Mouse) 12311