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产品信息
10120-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Calpain 6 Fusion Protein Ag0160 (67-360 aa encoded by BC000730)
偶联物
形式
Liquid
浓度
0.16 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NISNHQLTQ GRLGHKPMVS AFSCLAVQES HWTKTIPNHK EQEWDPQKTE KYAGIFHFRF WHFGEWTEVV IDDLLPTING DLVFSFSTSM NEFWNALLEK AYAKLLGCYE ALDGLTITDI IVDFTGTLAE TVDMQKGRYT ELVEEKYKLF GELYKTFTKG GLICCSIESP NQEEQEVETD WGLLKGHTYT MTDIRKIRLG ERLVEVFSAE KVYMVRLRNP LGRQEWSGPW SEISEEWQQL TASDRKNLGL VMSDDGEFWM SLEDFCRNFH KLNVCRNVNN PIFGRKELES VLGCW (67-360 aa encoded by B C000730)
靶标信息
Calpain-6, also known as calpamodulin or calpain-X, is an intracellular, calcium-dependent cysteine protease. Calpain-6 has a much more tissue-specific expression in adults than the ubiquitous calpain-1 and calpain-2, and has thus far been found primarily in the placenta, although it is expressed embryonically in a number of tissues. The classical calpain family members consist of a common small subunit (calpain-4), and a large variable subunit, but it is not known if calpain-6 associates with a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain T in calpains 5 and 6). Located on the X chromosome, the calpain-6 sequence lacks the "EF hand" calcium-binding motif found in domain-IV of the classical calpains. In addition, the canonical active site Cys, His and Asn are modified to Lys, His, Asn in human and Lys, Tyr, Asn in mouse calpain-6, making it unlikely that calpain-6 is proteolytically active.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Calpain-6; Calpain-like protease X-linked; Calpamodulin; CalpM
基因别名: CALPM; CANPX; Capa6; CAPN6; CAPNX; DJ914P14.1
UniProt ID: (Human) Q9Y6Q1, (Mouse) O35646, (Rat) O88501
Entrez Gene ID: (Human) 827, (Mouse) 12338, (Rat) 83685
