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Immunogen sequence: FAYPMPFCD RWGKLPLSPK QKTTFSKWVR PEDLTNNPTM IYTVSSFSIK QTIVSDCSFV ASLAISAAYE RRFNKKLITG IIYPQNKDGE PEYNPCGKYM VKLHLNGVPR KVIIDDQLPV DHKGELLCSY SNNKSELWVS LIEKAYMKVM GGYDFPGSNS NIDLHALTGW IPERIAMHSD SQTFSKDNSF RMLYQRFHKG DVLITASTGM MTEAEGEKWG LVPTHAYAVL DIREFKGLRF IQLKNPWSHL RWKGRYSEND VENWTPELQK YLNFDPRTAQ KIDNGIFWIS WDDLCQYYDV (235-533 aa encoded by BC056202)
Calpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain-4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain-7). Calpain-7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, calpain-7 has a sequence most closely resembling domain-III, with unknown function. Calpain-7 is widely distributed, found in most tissues analyzed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: calpain like protease; Calpain-7; homolog of Aspergillus Nidulans PALB; PalB homolog; PalBH
基因别名: AU022319; CALPAIN7; CAPN7; PALBH
UniProt ID: (Human) Q9Y6W3, (Mouse) Q9R1S8
Entrez Gene ID: (Human) 23473, (Rat) 306260, (Mouse) 12339