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Recommended positive controls: 293T, A431, Jurkat, Raji.
Predicted reactivity: Mouse (89%), Rat (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Calpain-9; Digestive tract-specific calpain; nCL-4; New calpain 4; novel calpain large subunit-4; Protein CG36
基因别名: CAPN9; GC36; nCL-4; NCL4
UniProt ID: (Human) O14815
Entrez Gene ID: (Human) 10753