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Carboxypeptidase E Antibody (PA5-109581) in WB
Western blot analysis of Carboxypeptidase E in extracts of various cell lines. Samples were incubated with Carboxypeptidase E Polyclonal antibody (Product # PA5-109581) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-109581
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 257-476 of human CPE (NP_001864.1).
偶联物
形式
Liquid
浓度
1.68 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2854992
产品详细信息
Immunogen sequence: PYDETRSGSA HEYSSSPDDA IFQSLARAYS SFNPAMSDPN RPPCRKNDDD SSFVDGTTNG GAWYSVPGGM QDFNYLSSNC FEITVELSCE KFPPEETLKT YWEDNKNSLI SYLEQIHRGV KGFVRDLQGN PIANATISVE GIDHDVTSAK DGDYWRLLIP GNYKLTASAP GYLAITKKVA VPYSPAAGVD FELESFSERK EEEKEELMEW WKMMSETLNF
靶标信息
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Carboxypeptidase E; Carboxypeptidase H; CarboxypeptidaseE; CarboxypeptidaseH; CBPE; cobalt-stimulated chromaffin granule carboxypeptidase; CPE; CPH; Cph 1; Enkephalin convertase; insulin granule-associated carboxypeptidase; Prohormone-processing carboxypeptidase
基因别名: CPE; CPH; Cph-1; Cph1; fat; R74677
UniProt ID: (Human) P16870, (Mouse) Q00493
Entrez Gene ID: (Human) 1363, (Mouse) 12876
carboxypeptidase activity
metallocarboxypeptidase activity
serine-type carboxypeptidase activity
zinc ion binding
neurexin family protein binding
cell adhesion molecule binding
peptidase activity
metallopeptidase activity
hydrolase activity
protein domain specific binding
metal ion binding
cobalt ion binding
protease
cardiac left ventricle morphogenesis
cellular protein modification process
neuropeptide signaling pathway
metabolic process
Wnt signaling pathway
insulin processing
protein localization to membrane
proteolysis
peptide metabolic process
protein processing
enkephalin processing
peptide catabolic process
negative regulation of branching morphogenesis of a nerve
