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Invitrogen
Cardiac Troponin T Recombinant Rabbit Monoclonal Antibody (ARC1242)
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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Cardiac Troponin T Antibody (MA5-35608) in ICC/IF
Immunofluorescence analysis of Cardiac Troponin T was performed using 70% confluent log phase H9 differentiated to cardiomyocytes. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for overnight at room temperature. The cells were labeled with Cardiac Troponin T Recombinant Rabbit Monoclonal Antibody (ARC1242) (Product... View More
产品信息
MA5-35608
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1242
抗原
A synthetic peptide corresponding to a sequence within amino acids 199-298 of human Cardiac troponin T (TNNT2) (P45379)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849508
产品详细信息
Immunogen sequence: QKQAQTERKS GKRQTEREKK KKILAERRKV LAIDHLNEDQ LREKAKELWQ SIYNLEAEKF DLQEKFKQQK YEINVLRNRI NDNQKVSKTR GKAKVTGRWK
靶标信息
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cardiac muscle troponin T; cardiac TnT; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; cTnT; MGC3889; TnTc; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac muscle; Troponin T2; troponin T2, cardiac; truncated cardiac troponin T
基因别名: CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTC
UniProt ID: (Human) P45379, (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Human) 7139, (Rat) 24837, (Mouse) 21956
regulation of heart contraction
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
regulation of muscle filament sliding speed
protein heterooligomerization
response to calcium ion
actin crosslink formation
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle contraction
regulation of muscle contraction
heart development
metabolic process
sarcomere organization
atrial cardiac muscle tissue morphogenesis
