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Invitrogen

Caspase 3 Monoclonal Antibody (3CSP03 (4.1.18))

高级验证

1个已发表图片

8 篇参考文献

查看其他36个Caspase 3抗体

说明书

实验方案

技术支持

货号 MA5-11521

500 µL

说明书

实验方案

技术支持

Application

Caspase 3 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 12

Caspase 3 Antibody (MA5-11521) in ICC/IF

Immunofluorescence analysis of Caspase 3 was performed using 70% confluent log phase HeLa cells treated with 1 µg/mL Staurosporine for 5 hours. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Caspase 3 Monoclonal Antibody (3CSP03 (4.1.18)) (product # MA5-246... View More

Caspase 3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Caspase 3 Antibody in Immunoprecipitation (IP)

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产品信息

MA5-11521

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

查看6篇已发表文章 6篇已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

免疫细胞化学 (ICC/IF)

2 µg/mL

免疫沉淀 (IP)

2 µg/mg protein lysate

产品规格

种属反应

Human

已发表种属

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

3CSP03 (4.1.18)

抗原

Recombinant full length human Caspase 3 protein

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10979528

产品详细信息

MA5-11521 targets Caspase 3 in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with Human samples.

The MA5-11521 immunogen is recombinant full length human Caspase 3 protein.

靶标信息

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MYBL2 in synergy with CDC20 promotes the proliferation and inhibits apoptosis of gastric cancer cells.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Deng Q,Wu L,Li Y,Zou L

MA5-11521 was used in Western Blot to examine the role of myeloblastosis viral oncogene homolog-like 2 (MYBL2) in gastric cancer progression and investigate the underlying mechanisms.

Wed Sep 01 00:00:00 UTC 2021

Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury.

Stem cell research & therapy

Ullah M,Liu DD,Rai S,Razavi M,Concepcion W,Thakor AS

MA5-11521 was used in Western Blotting to show that pFUS may be a strategy for enhancing the therapeutic efficacy of MSC-derived EV treatment for the treatment of AKI.

Mon Sep 14 00:00:00 UTC 2020

Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury.

Stem cell research & therapy

Ullah M,Liu DD,Rai S,Razavi M,Concepcion W,Thakor AS

MA5-11521 was used in Western Blotting to show that pFUS may be a strategy for enhancing the therapeutic efficacy of MSC-derived EV treatment for the treatment of AKI.

Mon Sep 14 00:00:00 UTC 2020

Effects of caffeine on neuronal apoptosis in neonatal hypoxic-ischemic brain injury.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Kilicdag H,Daglioglu YK,Erdogan S,Zorludemir S

MA5-11521 was used in immunohistochemistry to study the effects of caffeine on hypoxia-ischemia-induced neuronal apoptosis in a neonatal rat model and the therapeutic implications for brain injury

Mon Sep 01 00:00:00 UTC 2014

Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program.

Cancer

Mitra AP,Castelao JE,Hawes D,Tsao-Wei DD,Jiang X,Shi SR,Datar RH,Skinner EC,Stein JP,Groshen S,Yu MC,Ross RK,Skinner DG,Cortessis VK,Cote RJ

MA5-11521 was used in immunohistochemistry to study the value of a panel of 9 biomarkers plus smoking intensity in predicting the outcome of bladder cancer

Fri Feb 15 00:00:00 UTC 2013

Human papillomavirus in oral atrophic lichen planus lesions.

Oral oncology

Mattila R,Rautava J,Syrjänen S

MA5-11521 was used in immunohistochemistry to study the involvement of human papillomavirus in oral atrophic lichen planus lesions

Mon Oct 01 00:00:00 UTC 2012

Increased vein wall apoptosis in varicose vein disease is related to venous hypertension.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Filis K,Kavantzas N,Isopoulos T,Antonakis P,Sigalas P,Vavouranakis E,Sigala F

MA5-11521 was used in immunohistochemistry to study the effect of venous hypertension on vein wall apoptosis in varicose vein disease

Fri Apr 01 00:00:00 UTC 2011

Immunohistochemical analysis of non-small cell lung cancer: correlation with clinical parameters and prognosis.

Journal of Korean medical science

Yoo J,Jung JH,Lee MA,Seo KJ,Shim BY,Kim SH,Cho DG,Ahn MI,Kim CH,Cho KD,Kang SJ,Kim HK

MA5-11521 was used in immunohistochemistry to study the immunohistochemistry of non-small cell lung cancer

Sun Apr 01 00:00:00 UTC 2007

Caspase-3 and caspase-6 in ductal breast carcinoma: a descriptive study.

Histology and histopathology

Blázquez S,Sirvent JJ,Olona M,Aguilar C,Pelegri A,Garcia JF,Palacios J

MA5-11521 was used in immunohistochemistry to study caspase-3 and caspase-6 expression in ductal breast carcinoma.

Fri Dec 01 00:00:00 UTC 2006

生物信息学

蛋白别名: Apopain; Apopain precursor; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase-3; Caspase3; CPP-32; Cysteine protease CPP32; ICE3; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; SREBP cleavage activity 1

基因别名: CASP3; CPP32; CPP32B; SCA-1

UniProt ID: (Human) P42574

Entrez Gene ID: (Human) 836

功能

protease binding aspartic-type endopeptidase activity cysteine-type endopeptidase activity cyclin-dependent protein serine/threonine kinase inhibitor activity death receptor binding protein binding peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process phospholipase A2 activator activity protein complex binding cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity involved in execution phase of apoptosis protease

参与通路

response to hypoxia B cell homeostasis apoptotic DNA fragmentation proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cellular component disassembly involved in execution phase of apoptosis cellular response to DNA damage stimulus heart development sensory perception of sound learning or memory activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c response to UV response to glucose response to X-ray regulation of macroautophagy protein processing hippocampus development neuron differentiation keratinocyte differentiation erythrocyte differentiation platelet formation negative regulation of B cell proliferation response to cobalt ion response to estradiol response to lipopolysaccharide glial cell apoptotic process response to tumor necrosis factor response to nicotine hippo signaling wound healing response to drug response to hydrogen peroxide T cell homeostasis negative regulation of apoptotic process response to amino acid positive regulation of neuron apoptotic process cell fate commitment negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of activated T cell proliferation response to antibiotic neurotrophin TRK receptor signaling pathway response to glucocorticoid neuron apoptotic process cellular response to organic cyclic compound apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand execution phase of apoptosis

Caspase 3 Monoclonal Antibody (3CSP03 (4.1.18))

Caspase 3 Antibody (MA5-11521) in ICC/IF

产品信息

MA5-11521

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

种属反应

已发表种属

宿主/亚型

分类

类型

克隆号

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

Caspase 3 Monoclonal Antibody (3CSP03 (4.1.18))

Caspase 3 Antibody (MA5-11521) in ICC/IF

产品信息

MA5-11521

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

种属反应

已发表种属

宿主/亚型

分类

类型

克隆号

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;}

产品详细信息

靶标信息

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