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Proteintech

Caspase 4/p20/p10 Polyclonal Antibody

11 篇参考文献

说明书

实验方案

技术支持

货号 11856-1-AP

此产品在中国无法购买

150 µL

说明书

实验方案

技术支持

抗体检测数据 (4)

Application

Caspase 4/p20/p10 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 4

Caspase 4/p20/p10 Antibody (11856-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 11856-1-AP (Caspase 4/p20/p10 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Caspase 4/p20/p10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Caspase 4/p20/p10 Antibody in Western Blot (WB)

Product Image Gallery

产品信息

11856-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看9篇已发表文章 9篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:50-1:500

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Caspase 4/p20/p10 Fusion Protein Ag2429 (1-377 aa encoded by BC017839)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.45 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MAEGNHRKK PLKVLESLGK DFLTGVLDNL VEQNVLNWKE EEKKKYYDAK TEDKVRVMAD SMQEKQRMAG QMLLQTFFNI DQISPNKKAH PNMEAGPPES GESTDALKLC PHEEFLRLCK ERAEEIYPIK ERNNRTRLAL IICNTEFDHL PPRNGADFDI TGMKELLEGL DYSVDVEENL TARDMESALR AFATRPEHKS SDSTFLVLMS HGILEGICGT VHDEKKPDVL LYDTIFQIFN NRNCLSLKDK PKVIIVQACR GANRGELWVR DSPASLEVAS SQSSENLEED AVYKTHVEKD FIAFCSSTPH NVSWRDSTMG SIFITQLITC FQKYSWCCHL EEVFRKVQQS FETPRAKAQM PTIERLSMTR YFYLFPGN (1-377 aa encoded by BC017839)

靶标信息

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.

Frontiers in immunology

Fu L,Bao J,Li J,Li Q,Lin H,Zhou Y,Li J,Yan Y,Langston ME,Sun T,Guo S,Zhou X,Chen Y,Liu Y,Zhao Y,Lu J,Huang Y,Chen W,Chung BI,Luo J

Tue Oct 18 00:00:00 UTC 2022

Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.

Frontiers in immunology

Fu L,Bao J,Li J,Li Q,Lin H,Zhou Y,Li J,Yan Y,Langston ME,Sun T,Guo S,Zhou X,Chen Y,Liu Y,Zhao Y,Lu J,Huang Y,Chen W,Chung BI,Luo J

Tue Oct 18 00:00:00 UTC 2022

International journal of general medicine

Zhou Z,Xu J,Huang N,Tang J,Ma P,Cheng Y

Sat Jul 16 00:00:00 UTC 2022

Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.

Inflammation

Ji Q,Wang L,Liu J,Wu Y,Lv H,Wen Y,Shi L,Qu B,Szentmáry N

Thu Apr 01 00:00:00 UTC 2021

Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.

Frontiers in microbiology

Wang B,Zhang C,Yu C,Zhu Y,Tang Q,Huang H,Zhao Z

Sun May 30 00:00:00 UTC 2021

IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.

Experimental and therapeutic medicine

Wang J,Yuan X,Ding N

Tue Jun 01 00:00:00 UTC 2021

Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.

Frontiers in microbiology

Ding PH,Yang MX,Wang NN,Jin LJ,Dong Y,Cai X,Chen LL

Mon Sep 28 00:00:00 UTC 2020

The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.

Stem cells international

Jiao Y,Wang L,Lu L,Liu J,Li X,Zhao H,Hou Z,Zheng B

Mon Sep 28 00:00:00 UTC 2020

Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.

Medical science monitor : international medical journal of experimental and clinical research

Xin XL,Zhang R,Yuan XM,Liu L

Sun Sep 22 00:00:00 UTC 2019

Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.

Chemical research in toxicology

Xia X,Lu B,Dong W,Yang B,Wang Y,Qin Q,Liu Z,Song E,Song Y

Mon Dec 17 00:00:00 UTC 2018

Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation.

Chemical research in toxicology

Xia X,Lu B,Dong W,Yang B,Wang Y,Qin Q,Liu Z,Song E,Song Y

Mon Dec 17 00:00:00 UTC 2018

Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.

International journal of molecular sciences

Shi WY,Cao C,Liu L

Wed Nov 02 00:00:00 UTC 2016

Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.

International journal of molecular sciences

Shi WY,Cao C,Liu L

Wed Nov 02 00:00:00 UTC 2016

生物信息学

蛋白别名: apoptotic cysteine protease Mih1/TX; CASP-4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; Mih1; protease ICH-2; Protease TX

基因别名: CASP4; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1; Mih1/TX; TX

UniProt ID: (Human) P49662

Entrez Gene ID: (Human) 837

功能

cysteine-type endopeptidase activity involved in apoptotic process protease

参与通路

proteolysis apoptotic process inflammatory response regulation of apoptotic process innate immune response regulation of inflammatory response intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway cellular response to beta-amyloid