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Invitrogen
Caspase 7 Polyclonal Antibody
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Caspase 7 Antibody (PA5-17910) in WB
Western blot was performed using Anti-Caspase 7 Polyclonal Antibody (Product # PA5-17910) and a 35kDa band corresponding to Caspase-7 and a 20kDa band corresponding to the cleaved form of Caspase-7 (in Jurkat and HeLa) were observed upon Etoposide and Staurosporine treatment. An uncharacterized band around 65kDa was also observed in PC-12. Expression of Caspase-7 in Brain is low compared to Spleen. Whole cell extracts (30 µg lysate) of Jurkat (Lane 1), Jurkat treated with Etoposide (25uM for 16hr) (Lane 2), HeLa (Lane 3), HeLa treated with... View More
产品信息
PA5-17910
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues surrounding the cleavage site of human caspase-7
偶联物
形式
Liquid
浓度
603 µg/mL
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10984995
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apoptotic protease Mch-3; CASP-7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; CMH-1; Cysteine protease LICE2; ICE-LAP3; ICE-like apoptotic protease 3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6
基因别名: AI314680; CASP-7; CASP7; caspase-7; CMH-1; ICE-IAP3; ICE-LAP3; LICE2; mCASP-7; MCH3
UniProt ID: (Human) P55210, (Mouse) P97864
Entrez Gene ID: (Human) 840, (Rat) 64026, (Mouse) 12369
cysteine-type endopeptidase activity
protein binding
cysteine-type peptidase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity involved in apoptotic process
peptidase activity
hydrolase activity
protease
proteolysis
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
execution phase of apoptosis
release of cytochrome c from mitochondria
heart development
aging
response to UV
protein processing
positive regulation of neuron apoptotic process
neuron apoptotic process
